雌二醇对雌性家兔十二指肠肌电活动的作用研究

doi:10.11843/j.issn.0366-6964.2018.10.023

Abstract

Abstract:

The objective of this study was to clarify the regulation of estrogen on the duodenal myoelectric motility and to screen and establish the mathematical model between the monitoring index of monitoring duodenal myoelectric activity and the concertration of estrogen. The ovariectomized and electrode embedded animal models of experimental rabbits were constructed and the different doses of estradiol benzoate were injected intramuscularly. The changes of myoelectric activity in duodenum of rabbits in each group were recorded by BL-420F biological function test system and the results were statistically analyzed. The optimal mathematical model of monitoring index between duodenal electromyography and estradiol benzoate was selected and constructed according to the function fitting accuracy analysis of each monitoring index. The results showed that the amplitude, frequency and the index of myoelectric activity of duodenal myoelectricity were all increased first, and then decreased with the increase of estradiol benzoate dose. The functional model of the relationship between the dosage of estradiol and the index of myoelectric activity was established through the analysis and screening of each monitoring index. The analysis results of this function showed that the index of myoelectric activity was changed on the range from 1.50 to 5.23 mV·min^-1, and the maximum value reached 5.23 mV·min^-1 when the dose of estradiol reached 0.098 mg·kg^-1. In addition, the trend of the index of myoelectric activity with the increase of estradiol dose could be divided into four intervals containing exponential increase, logarithmic increase, exponential decrease and logarithmic decrease with the estradiol dosage of 0.063, 0.098 and 0.133 mg·kg^-1 as the cutting point. The above results suggest that estradiol has a concentration-dependent dual regulatory effect on duodenal myoelectric activity, and this regulation is based on a certain level of myoelectric activity in the duodenum. The regulation of estrogen on duodenal myoelectric activity is indirect. In addition, the myoelectric activity of duodenum showed different tendency under the action of estrogen in different concentration and presented obvious interval effect. The results of this study provide a theoretical basis and reference for elucidating the regulation mode of estrogen in the regulation of duodenal movement in vivo and the development and application of estrogenic drugs.

CLC Number:

S852.2

DU Yi-nan, GUO Ya-ru, ZHAO Jian-shuai, ZHANG Jin, XIN Xian-meng, MA Yi-jia, HE Xue-min, XU Yong-ping. The Effect of Estrogen on the Regulation of Duodenal Myoelectric Activity of Female Rabbit[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(10): 2268-2275.

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The Effect of Estrogen on the Regulation of Duodenal Myoelectric Activity of Female Rabbit

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